This movie is about Alex, a returning college student who moves in with her girlfriends after the holidays. They go out and have quite a few drinks and on the way home Alex and her friend Jessica go to a psychic where Alex has an episode and freaks out her friend and the psychic. The next day Alex doesn't have any memory of what happened and her friends think there's something going on with her. Over time, she starts having things happen to her, scratches, visions and ultimately rape from some being. Her friends start to worry about her even more and things take a turn for the worst when she loses control. What is inside her, and will they all live?

An American girl, Isabella, sets out to make a documentary to understand what happened to her mother who murdered three clergy people. She was not convicted due to insanity and was sent to a mental hospital in Italy. Isabella meets with some priests in Italy who explain that her mother's condition may not be medical, but could be an extra-human possession.

Seventeen year-old Nell Margaret Sweetzer is found completely insane when trying to explain her possession by the demon called Abalam. After medical and psychological treatment, she is sent to the Deveraux transition house in New Orleans managed by Frank Merle, who helps her to start a new life. She finds a job as a hotel housekeeper, befriends her new roommates, and develops a crush on her coworker, Chris. Soon, Nell comes to realize that she is haunted by people from her cult... and by the same evil force that once possessed her. When Nell meets Miss Cecile, she tells Nell that she has been following her since the hospital. Further, she discloses that she belongs to the sect Order of The Right Hand, and that they can protect her from the evil in an attempt to divert the prophecy of an apocalypse. Will Nell accept help, and be protected from the extremely powerful, evil force Abalam -- Or will she come to accept... herself?

Documentary covering the famous 'demonic possession' case of Anneliese Michel. The film features authentic footage of 'exorcisms' and other shocking events, considered to be the inspiration of the film .